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Elevated glutamine metabolism makes cancer cells more susceptible to glutamine deficiency caused by glutaminase inhibitors, which rapidly induces cell death [122]

Since is positivenegativeincreasingdecreasing when is positive and positivenegativeincreasingdecreasing when is negative, we see Since is increasing when is positivenegativeincreasingdecreasing and decreasing when is positivenegativeincreasingdecreasing , we see Hence , , and .

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